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Warfarin sensitivity

MedGen UID:
392858
•Concept ID:
C2608079
•
Finding
Synonym: Warfarin Sensitivity
SNOMED CT: Warfarin sensitivity (726543008)
 
OMIM®: 122700; 601130; 608547

Professional guidelines

PubMed

Differences in Predicted Warfarin Dosing Requirements Between Hmong and East Asians Using Genotype-Based Dosing Algorithms.
Sun B, Wen YF, Culhane-Pera KA, Lo M, Xiong T, Lee K, Peng K, Thyagarajan B, Bishop JR, Zierhut H, Straka RJ
Pharmacotherapy 2021 Mar;41(3):265-276. Epub 2020 Dec 21 doi: 10.1002/phar.2487. PMID: 33202062
Genetic influence on bleeding and over-anticoagulation risk in patients undergoing warfarin treatment after heart valve replacements.
Zhou L, Ding Y, Gao Y, Yang B, Bao J, Ma J
Expert Opin Drug Metab Toxicol 2020 Jan;16(1):1-9. Epub 2020 Jan 9 doi: 10.1080/17425255.2020.1711883. PMID: 31914334
Warfarin pharmacogenetics: does more accurate dosing benefit patients?
Eby C
Semin Thromb Hemost 2012 Oct;38(7):661-6. Epub 2012 Oct 9 doi: 10.1055/s-0032-1326789. PMID: 23047421Free PMC Article

Recent clinical studies

Etiology

Warfarin-Rifampin-Gene (WARIF-G) Interaction: A Retrospective, Genetic, Case-Control Study.
Salem M, El-Bardissy A, Elshafei MN, Khalil A, Mahmoud H, Fahmi AM, Kasem M, Bader L, Sherbash M, Elawady MI, Abdalazim W, Howady F, Elewa H
Clin Pharmacol Ther 2023 May;113(5):1150-1159. Epub 2023 Mar 9 doi: 10.1002/cpt.2871. PMID: 36789833
Is there a circannual variation in the anticoagulation control of warfarin?
Sridharan K, Al Banna R, Husain A
Eur J Hosp Pharm 2023 Jan;30(1):41-45. Epub 2021 Apr 26 doi: 10.1136/ejhpharm-2021-002793. PMID: 33903173Free PMC Article
Warfarin sensitivity is associated with increased hospital mortality in critically Ill patients.
Ma Z, Wang P, Mahesh M, Elmi CP, Atashpanjeh S, Khalighi B, Cheng G, Krishnamurthy M, Khalighi K
PLoS One 2022;17(5):e0267966. Epub 2022 May 5 doi: 10.1371/journal.pone.0267966. PMID: 35511891Free PMC Article
Clinical Model for Predicting Warfarin Sensitivity.
Ma Z, Cheng G, Wang P, Khalighi B, Khalighi K
Sci Rep 2019 Sep 6;9(1):12856. doi: 10.1038/s41598-019-49329-0. PMID: 31492893Free PMC Article
Genetics and clinical response to warfarin and edoxaban in patients with venous thromboembolism.
Vandell AG, Walker J, Brown KS, Zhang G, Lin M, Grosso MA, Mercuri MF
Heart 2017 Nov;103(22):1800-1805. Epub 2017 Jul 8 doi: 10.1136/heartjnl-2016-310901. PMID: 28689179Free PMC Article

Diagnosis

Warfarin-Rifampin-Gene (WARIF-G) Interaction: A Retrospective, Genetic, Case-Control Study.
Salem M, El-Bardissy A, Elshafei MN, Khalil A, Mahmoud H, Fahmi AM, Kasem M, Bader L, Sherbash M, Elawady MI, Abdalazim W, Howady F, Elewa H
Clin Pharmacol Ther 2023 May;113(5):1150-1159. Epub 2023 Mar 9 doi: 10.1002/cpt.2871. PMID: 36789833
Clinical Model for Predicting Warfarin Sensitivity.
Ma Z, Cheng G, Wang P, Khalighi B, Khalighi K
Sci Rep 2019 Sep 6;9(1):12856. doi: 10.1038/s41598-019-49329-0. PMID: 31492893Free PMC Article
Warfarin and vitamin K intake in the era of pharmacogenetics.
Lurie Y, Loebstein R, Kurnik D, Almog S, Halkin H
Br J Clin Pharmacol 2010 Aug;70(2):164-70. doi: 10.1111/j.1365-2125.2010.03672.x. PMID: 20653669Free PMC Article
Warfarin sensitivity genotyping: a review of the literature and summary of patient experience.
Moyer TP, O'Kane DJ, Baudhuin LM, Wiley CL, Fortini A, Fisher PK, Dupras DM, Chaudhry R, Thapa P, Zinsmeister AR, Heit JA
Mayo Clin Proc 2009 Dec;84(12):1079-94. doi: 10.4065/mcp.2009.0278. PMID: 19955245Free PMC Article
Pharmacogenetic testing for warfarin sensitivity.
Lyon E, McMillin G, Melis R
Clin Lab Med 2008 Dec;28(4):525-37. doi: 10.1016/j.cll.2008.09.001. PMID: 19059060

Therapy

Warfarin-Rifampin-Gene (WARIF-G) Interaction: A Retrospective, Genetic, Case-Control Study.
Salem M, El-Bardissy A, Elshafei MN, Khalil A, Mahmoud H, Fahmi AM, Kasem M, Bader L, Sherbash M, Elawady MI, Abdalazim W, Howady F, Elewa H
Clin Pharmacol Ther 2023 May;113(5):1150-1159. Epub 2023 Mar 9 doi: 10.1002/cpt.2871. PMID: 36789833
Is there a circannual variation in the anticoagulation control of warfarin?
Sridharan K, Al Banna R, Husain A
Eur J Hosp Pharm 2023 Jan;30(1):41-45. Epub 2021 Apr 26 doi: 10.1136/ejhpharm-2021-002793. PMID: 33903173Free PMC Article
Clinical Model for Predicting Warfarin Sensitivity.
Ma Z, Cheng G, Wang P, Khalighi B, Khalighi K
Sci Rep 2019 Sep 6;9(1):12856. doi: 10.1038/s41598-019-49329-0. PMID: 31492893Free PMC Article
Warfarin sensitivity genotyping: a review of the literature and summary of patient experience.
Moyer TP, O'Kane DJ, Baudhuin LM, Wiley CL, Fortini A, Fisher PK, Dupras DM, Chaudhry R, Thapa P, Zinsmeister AR, Heit JA
Mayo Clin Proc 2009 Dec;84(12):1079-94. doi: 10.4065/mcp.2009.0278. PMID: 19955245Free PMC Article
Pharmacogenetic testing for warfarin sensitivity.
Lyon E, McMillin G, Melis R
Clin Lab Med 2008 Dec;28(4):525-37. doi: 10.1016/j.cll.2008.09.001. PMID: 19059060

Prognosis

Warfarin sensitivity is associated with increased hospital mortality in critically Ill patients.
Ma Z, Wang P, Mahesh M, Elmi CP, Atashpanjeh S, Khalighi B, Cheng G, Krishnamurthy M, Khalighi K
PLoS One 2022;17(5):e0267966. Epub 2022 May 5 doi: 10.1371/journal.pone.0267966. PMID: 35511891Free PMC Article
Nine-gene pharmacogenomics profile service: The Mayo Clinic experience.
Matey ET, Ragan AK, Oyen LJ, Vitek CR, Aoudia SL, Ragab AK, Fee-Schroeder KC, Black JL, Moyer AM, Nicholson WT, Shrestha S, McAllister TM, Sinnwell JP, Faubion SS, Lazaridis KN
Pharmacogenomics J 2022 Feb;22(1):69-74. Epub 2021 Oct 20 doi: 10.1038/s41397-021-00258-0. PMID: 34671112
Clinical Model for Predicting Warfarin Sensitivity.
Ma Z, Cheng G, Wang P, Khalighi B, Khalighi K
Sci Rep 2019 Sep 6;9(1):12856. doi: 10.1038/s41598-019-49329-0. PMID: 31492893Free PMC Article
Artificial neural network-based pharmacogenomic algorithm for warfarin dose optimization.
Pavani A, Naushad SM, Kumar RM, Srinath M, Malempati AR, Kutala VK
Pharmacogenomics 2016;17(2):121-31. Epub 2015 Dec 15 doi: 10.2217/pgs.15.161. PMID: 26666467
Clinical Predictors Associated With Warfarin Sensitivity.
Saleh MI
Am J Ther 2016 Nov/Dec;23(6):e1690-e1694. doi: 10.1097/MJT.0000000000000248. PMID: 25830869

Clinical prediction guides

Is there a circannual variation in the anticoagulation control of warfarin?
Sridharan K, Al Banna R, Husain A
Eur J Hosp Pharm 2023 Jan;30(1):41-45. Epub 2021 Apr 26 doi: 10.1136/ejhpharm-2021-002793. PMID: 33903173Free PMC Article
Warfarin sensitivity is associated with increased hospital mortality in critically Ill patients.
Ma Z, Wang P, Mahesh M, Elmi CP, Atashpanjeh S, Khalighi B, Cheng G, Krishnamurthy M, Khalighi K
PLoS One 2022;17(5):e0267966. Epub 2022 May 5 doi: 10.1371/journal.pone.0267966. PMID: 35511891Free PMC Article
Clinical Model for Predicting Warfarin Sensitivity.
Ma Z, Cheng G, Wang P, Khalighi B, Khalighi K
Sci Rep 2019 Sep 6;9(1):12856. doi: 10.1038/s41598-019-49329-0. PMID: 31492893Free PMC Article
Clinical Predictors Associated With Warfarin Sensitivity.
Saleh MI
Am J Ther 2016 Nov/Dec;23(6):e1690-e1694. doi: 10.1097/MJT.0000000000000248. PMID: 25830869
Changes in Warfarin Sensitivity During Decompensated Heart Failure and Chronic Obstructive Pulmonary Disease.
del Campo M, Roberts G
Ann Pharmacother 2015 Sep;49(9):962-8. Epub 2015 Jun 23 doi: 10.1177/1060028015590438. PMID: 26104049

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